Beitrag
von Dr. med. Ron Lehnert » 21.07.2008, 22:34
Hier ist die Studie dazu:
1: J Refract Surg. 2008 Apr;24(4):337-43.
Cyclosporine 0.05% ophthalmic preparation to aid recovery from loss of corneal
sensitivity after LASIK.
Peyman GA, Sanders DR, Batlle JF, Féliz R, Cabrera G.
Department of Ophthalmology, University of Arizona, Phoenix, Ariz., USA.
PURPOSE: To determine whether cyclosporine (0.05%) can safely and effectively
accelerate corneal nerve regeneration after LASIK, thereby facilitating faster
recovery of corneal sensitivity. METHODS: This prospective, randomized,
single-center clinical study comprised 44 eyes of 22 patients scheduled to
undergo bilateral LASIK. One eye was randomly assigned to receive cyclosporine
drops twice daily for 3 months in addition to standard postoperative LASIK
medication. Corneal sensitivity was measured using the Cochet-Bonnet
esthesiometer in four areas outside and five areas inside the LASIK flap
preoperatively and at 1 day, 1 week, 1 month, and 3 months postoperatively.
Safety parameters of best spectacle-corrected visual acuity and the incidence of
adverse events were also collected. RESULTS: For all four points outside the
LASIK flap, normal corneal sensitivity was maintained throughout the study. In
addition, no significant difference was found between the cyclosporine-treated
eyes and the control eyes at these points. All points within the LASIK flap
except the point closest to the hinge demonstrated profound corneal hypoesthesia
at 1 day, 1 week, and 1 month postoperatively with no differences noted between
the control and cyclosporine-treated eyes. These same points had statistically
significantly greater corneal sensitivity in the cyclosporine group relative to
the control group (P< or =.011) at 3 months postoperatively. CONCLUSIONS:
Cyclosporine was shown to significantly improve corneal sensitivity at 3 months
after LASIK, which suggests that topical cyclosporine promotes enhanced corneal
nerve regeneration.
PMID: 18500081 [PubMed - indexed for MEDLINE]
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